[Federal Register Volume 78, Number 14 (Tuesday, January 22, 2013)]
[Notices]
[Pages 4419-4421]
From the Federal Register Online via the Government Printing Office [www.gpo.gov]
[FR Doc No: 2013-01242]
-----------------------------------------------------------------------
DEPARTMENT OF HEALTH AND HUMAN SERVICES
National Institutes of Health
Draft Report on Carcinogens Monographs for 1-Bromopropane and
Cumene; Availability of Documents; Request for Comments; Notice of
Meeting
SUMMARY: Peer review meeting of the Draft Report on Carcinogens (RoC)
Monographs for 1-Bromopropane and Cumene. These documents were prepared
by the Office of the Report on Carcinogens (ORoC), Division of the
National Toxicology Program (DNTP), National Institute of Environmental
Health Sciences (NIEHS).
DATES: Meeting: March 21, 2013, 1:00 p.m. to approximately 5:00 p.m.
Eastern Daylight Time (EDT) and March 22, 2013, from 8:30 a.m. until
adjournment, approximately 2:00 p.m. EDT.
Document Availability: Draft monographs will be available by
January
[[Page 4420]]
23, 2013, at http://ntp.niehs.nih.gov/go/36639.
Public Comments Submissions: Deadline is March 7, 2013.
Pre-Registration for Meeting and/or Oral Comments: Deadline is
March 19, 2013.
ADDRESSES: Meeting Location: NIEHS, Keystone Building, Room 1003AB, 530
Davis Drive, Morrisville, NC 27560.
Agency Meeting Web page: The draft monographs, draft agenda,
registration and other meeting materials are at http://ntp.niehs.nih.gov/go/36639.
Webcast: The meeting will be available via webcast at http://www.niehs.nih.gov/news/video/index.cfm.
FOR FURTHER INFORMATION CONTACT: Dr. Lori D. White, NTP Designated
Federal Official, Office of Liaison, Policy and Review, DNTP, NIEHS,
P.O. Box 12233, MD K2-03, Research Triangle Park, NC 27709. Phone:
(919) 541-9834, Fax: (301) 480-3272, Email: whiteld@niehs.nih.gov. Hand
Delivery/Courier: 530 Davis Drive, Room 2136, Morrisville, NC 27560.
SUPPLEMENTARY INFORMATION: Background: The Report on Carcinogens (RoC)
is a congressionally mandated, science-based, public health report that
identifies agents, substances, mixtures, or exposures (collectively
called ``substances'') in our environment that may put people in the
United States at increased risk for cancer. The NTP prepares the RoC on
behalf of the Secretary of Health and Human Services.
The NTP follows an established, four-part process for preparation
of the RoC (http://ntp.niehs.nih.gov/go/rocprocess). A RoC Monograph is
prepared for each candidate substance selected for review for the RoC.
1-Bromopropane and cumene were selected as candidate substances
following solicitation of public comment and review by the NTP Board of
Scientific Counselors review on June 21-22, 2012 (http://ntp.niehs.nih.gov/go/9741). A draft RoC monograph consists of a (1)
cancer evaluation component that reviews all information that may bear
on a listing decision, assesses its quality and sufficiency for
reaching a listing decision, applies the RoC listing criteria to the
relevant scientific information, and recommends a listing status for
the candidate substance in the RoC and (2) a substance profile that
contains the NTP's preliminary listing recommendation and a summary of
the scientific evidence considered key to reaching that recommendation.
This meeting is planned for peer review of the draft RoC Monographs for
1-bromopropane and cumene.
1-Bromopropane (CASRN 106-94-5) is a brominated hydrocarbon that is
currently used as a solvent in a variety of industrial and commercial
applications. It is used as a solvent cleaner to degrease electronics,
precision optics, and metals, as a solvent vehicle in industries that
use aerosolized adhesives (e.g., foam cushion manufacturing), as a spot
remover in the textile industry, and as a solvent in the dry cleaning
industry. Additional information about the review of 1-bromopropane for
the RoC is available at http://ntp.niehs.nih.gov/go/37896.
Cumene (CASRN 98-82-8, isopropylbenzene) is an alkylated benzene
found in fossil fuels, such as blended gasoline and kerosene, and
products of incomplete combustion. It is a high production volume
chemical in the United States with the majority of its use in the
synthesis of acetone and phenol. Additional information about the
review of cumene for the RoC is available at http://ntp.niehs.nih.gov/go/37895.
Meeting and Registration: The meeting is open to the public with
time set aside for oral public comment; attendance at the NIEHS is
limited only by the space available. The meeting is scheduled for March
21, 2013, 1:00 p.m. to approximately 5:00 p.m. EDT and March 22, 2013,
from 8:30 a.m. until adjournment, approximately 2:00 p.m. EDT. Two days
are set aside for the meeting; however, it may adjourn sooner if the
panel completes its peer review of the draft monographs. Pre-
registration to attend the meeting and/or provide oral comments is by
March 19, 2013, at http://ntp.niehs.nih.gov/go/36639. Visitor and
security information is available at http://www.niehs.nih.gov/about/visiting/index.cfm. Individuals with disabilities who need
accommodation to participate in this event should contact Danica
Andrews at phone: (919) 541-2595 or email: andrewsda@niehs.nih.gov. TTY
users should contact the Federal TTY Relay Service at (800) 877-8339.
Requests should be made at least five business days in advance of the
event.
The preliminary agenda and draft monographs should be posted on the
NTP Web site (http://ntp.niehs.nih.gov/go/36639) by January 23, 2013.
Additional information will be posted when available or may be
requested in hardcopy, see FOR FURTHER INFORMATION CONTACT. Following
the meeting, a report of the peer review will be prepared and made
available on the NTP Web site. Registered attendees are encouraged to
access the meeting Web page to stay abreast of the most current
information regarding the meeting.
Request for Comments: The NTP invites written and oral public
comments on the draft monographs. The deadline for submission of
written comments is March 7, 2013, to enable review by the peer review
panel and NTP staff prior to the meeting. Pre-registration to provide
oral comments is by March 19, 2013, at http://ntp.niehs.nih.gov/go/36639. Public comments and any other correspondence on the draft
monographs should be sent to the FOR FURTHER INFORMATION CONTACT.
Persons submitting written comments should include their name,
affiliation, mailing address, phone, email, and sponsoring organization
(if any) with the document. Written comments received in response to
this notice will be posted on the NTP Web site, and the submitter will
be identified by name, affiliation, and/or sponsoring organization.
Public comment at this meeting is welcome, with time set aside for
the presentation of oral comments on the draft monographs. In addition
to in-person oral comments at the meeting at the NIEHS, public comments
can be presented by teleconference line. There will be 50 lines for
this call; availability will be on a first-come, first-served basis.
The lines will be open from 1:00 p.m. until approximately 5:00 p.m. EDT
on March 21 and from 8:30 a.m. EDT until adjournment on March 22,
although oral comments will be received only during the formal public
comment periods indicated on the preliminary agenda. Each organization
is allowed one time slot. At least 7 minutes will be allotted to each
speaker, and if time permits, may be extended to 10 minutes at the
discretion of the chair. Persons wishing to make an oral presentation
are asked to register online at http://ntp.niehs.nih.gov/go/36639 by
March 19, 2013, and if possible, to send a copy of their slides and/or
statement or talking points at that time. Written statements can
supplement and may expand the oral presentation. Registration for oral
comments will also be available at the meeting, although time allowed
for presentation by on-site registrants may be less than that for pre-
registered speakers and will be determined by the number of speakers
who register on-site.
Background Information on the RoC: Published biennially, each
edition of the RoC is cumulative and consists of substances newly
reviewed in addition to those listed in previous editions. The 12th
RoC, the latest edition, was published on June 10, 2011 (available at
[[Page 4421]]
http://ntp.niehs.nih.gov/go/roc12). The 13th RoC is under development.
For each listed substance, the RoC contains a substance profile, which
provides information on: Cancer studies that support the listing--
including those in humans, animals, and studies on possible mechanisms
of action--information about potential sources of exposure to humans,
and current Federal regulations to limit exposures.
Background Information on NTP Peer Review Panels: NTP panels are
technical, scientific advisory bodies established on an ``as needed''
basis to provide independent scientific peer review and advise the NTP
on agents of public health concern, new/revised toxicological test
methods, or other issues. These panels help ensure transparent,
unbiased, and scientifically rigorous input to the program for its use
in making credible decisions about human hazard, setting research and
testing priorities, and providing information to regulatory agencies
about alternative methods for toxicity screening. The NTP welcomes
nominations of scientific experts for upcoming panels. Scientists
interested in serving on an NTP panel should provide a current
curriculum vitae to the FOR FURTHER INFORMATION CONTACT. The authority
for NTP panels is provided by 42 U.S.C. 217a; section 222 of the Public
Health Service (PHS) Act, as amended. The panel is governed by the
Federal Advisory Committee Act, as amended (5 U.S.C. Appendix 2), which
sets forth standards for the formation and use of advisory committees.
Dated: January 16, 2013.
John R. Bucher,
Associate Director, National Toxicology Program.
[FR Doc. 2013-01242 Filed 1-18-13; 8:45 am]
BILLING CODE 4140-01-P