[Federal Register Volume 78, Number 39 (Wednesday, February 27, 2013)]
[Notices]
[Pages 13352-13354]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 2013-04443]
-----------------------------------------------------------------------
DEPARTMENT OF HEALTH AND HUMAN SERVICES
National Institutes of Health
Government-Owned Inventions; Availability for Licensing
AGENCY: National Institutes of Health, Public Health Service, HHS.
ACTION: Notice.
-----------------------------------------------------------------------
SUMMARY: The inventions listed below are owned by an agency of the U.S.
Government and are available for licensing in the U.S. in accordance
with 35 U.S.C. 207 to achieve expeditious commercialization of results
of federally-funded research and development. Foreign patent
applications are filed on selected inventions to extend market coverage
for companies and may also be available for licensing.
FOR FURTHER INFORMATION CONTACT: Licensing information and copies of
the U.S. patent applications listed below may be obtained by writing to
the indicated licensing contact at the Office of Technology Transfer,
National Institutes of Health, 6011 Executive Boulevard, Suite 325,
Rockville, Maryland 20852-3804; telephone: 301-496-7057; fax: 301-402-
0220. A signed Confidential Disclosure Agreement will be required to
receive copies of the patent applications.
Java Software for Investigational Drug Clinical Research
Description of Technology: A Java based software application
available for academic use and on a royalty-bearing basis for
commercial licensing. The Investigational Drug Management System (IDMS)
supports the operational needs of the investigation drug section of a
pharmacy providing inventory management functions which fulfill the
recordkeeping requirements defined in the Code of Federal Regulations
related to the storage, labeling, handling, and dispensing of
investigational drugs. The internet/browser based application
interfaces with the Computerized Provider Order Entry (CPOE) system for
[[Page 13353]]
tracking patients and prescriptions for investigational drugs. The IDMS
supports the prescription filling process by capturing real-time data
during the dispensing activity where automated safety checks are
performed, ensuring the ``five rights'' of medication use are
satisfied. The system supports randomized double-blind clinical trials
by generating complex, multi-tiered randomization schemes that produce
patient-specific treatment assignments along with industry standard
labels containing barcodes. IDMS serves as the book of record providing
end-to-end traceability for the receipt of raw materials from their
source to the dispensing of finished pharmaceutical dosage forms to
patients.
Potential Commercial Applications:
Clinical data management
Clinical Trials
Investigational new drug trials
Competitive Advantages:
Web based
User friendly
Data portability
Randomization tables
Development Stage:
Prototype
Clinical
Inventors: Richard O. DeCederfelt, George J. Grimes, Stephen M.
Bergstrom, Jon W. McKeeby (all of NIH-CC).
Intellectual Property: HHS Reference No. E-063-2013/0--Research
Tool. Patent protection is not being pursued for this technology.
Licensing Contact: Michael Shmilovich; 301-435-5019;
[email protected].
Software To Improve the Quality of Microscopy Images
Description of Technology: Available for licensing and commercial
use is software based on an iterative deconvolution procedure that
recovers images that have been blurred by a known point spread
function. The software provides superior results when multiple
independent observations of the same specimen are obtained. An example
of such observations might be the multiple views of a specimen
collected by a selective illumination plane microscope (SPIM). By using
the blurring function and observations (raw images) corresponding to
each view in sequential order through the iteration loop, the resulting
output contains higher resolution, contrast, and signal than would
result if any single observation alone was used, or if the output from
single deconvolution operations on each image are combined, e.g. by
averaging. In its current form, the software has been tested on the
Richardson-Lucy deconvolution (RLD) procedure. Preliminary data
indicate that the algorithm provides an isotropic resolution of 350 nm,
greatly improving the raw data (lateral resolution 0.5 microns, axial
resolution 1.5 microns) on nematode embryos. In vivo data illustrating
the power of the algorithm are available upon request.
Potential Commercial Applications:
Image Resolution
Sub-micron microscopy
Competitive Advantages:
Enables isotopic resolution
Iterative deconvolution algorithm that can readily be applied
to SPIM datasets
Development Stage:
Prototype
In vitro data available
In vivo data available (animal)
Inventors: Hari Shroff, Andrew York, Yicong Wu (all of NIBIB).
Publications:
1. Swoger J, et al. Multi-view image fusion improves resolution in
three-dimensional microscopy. Opt Express. 2007 Jun 25;15(13):8029-
42. [PMID 19547131]
2. Verveer PJ, et al. High-resolution three-dimensional imaging of
large specimens with light sheet-based microscopy. Nat Methods. 2007
Apr;4(4):311-3. [PMID 17339847]
Intellectual Property: HHS Reference No. E-062-2013/0--Software
Tool. Patent protection is not being pursued for this technology.
Licensing Contact: Michael Shmilovich; 301-435-5019;
[email protected].
Collaborative Research Opportunity: The NIBIB Section on High
Resolution Optical Imaging is seeking statements of capability or
interest from parties interested in collaborative research to further
develop, evaluate, or commercialize our algorithm, especially with
respect to multiview microscopes. For collaboration opportunities,
please contact Hari Shroff at [email protected].
Background-Free Fluorescent Nanodiamond Imaging
Description of Technology: Available for licensing and commercial
development are intellectual property rights covering a method of
imaging a biological specimen (e.g., human tissue) using fluorescent
nanodiamonds implanted into the subject of interest, applying a
magnetic field to said subject and producing a resultant image by a net
juxtaposition of a second acquired image. This process suppresses the
background and permits selective imaging of the nanodiamonds in the
presence of background fluorescence that exceeds the signal from the
nanodiamonds. Another aspect of the invention provides an imaging
method in which the resulting image is acquired by applying time-
varying magnetic fields using one or more secondary image averaged
against the first. The technique relies on imposing a small (~100
Gauss) magnetic field on the sample of interest during optical imaging
combined with post-processing of the acquired images to remove the
background. This technology can readily be added onto any commercial
optical imaging platform to achieve background-free images of the
nanodiamonds in a biological specimen.
Potential Commercial Applications:
In vitro and in vivo optical imaging and diagnostics
MRI imaging
Competitive Advantages:
Improved resolution through composite imagery
Background elimination
Indefinite tracking due to the exceptional stability of the
fluorescent nanodiamonds
Wide excitation band (~500-600 nm)
Broad-band Near IR emission (600-700 nm)
Nanodiamonds are stable in aqueous solution
In related technologies we have developed a method to
specifically coat and functionalize nanodiamonds for targeting and
labeling applications
Development Stage:
Prototype
In vitro data available
In vivo data available (animal)
Inventors: Susanta Sarkar, Ambika Bumb, Keir Neuman (all of NHLBI).
Intellectual Property: HHS Reference No. E-261-2012/0--US
Provisional Application No. 61/711,702 filed 09 Oct 2012.
Related Technology: HHS Reference No. E-175-2012/0--US Provisional
Application No. 61/672,996 filed 18 Jul 2012, ``Method of Preparing
Silica-coated Nanodiamonds.''
Licensing Contact: Michael Shmilovich; 301-435-5019;
[email protected].
Collaborative Research Opportunity: The NHLBI Laboratory of Single
Molecule Biophysics is seeking statements of capability or interest
from parties interested in collaborative research to further develop,
evaluate, or commercialize background-free imaging of fluorescent
nanodiamonds for in vivo and in vitro applications. For collaboration
opportunities, please contact Keir C. Neuman, Ph.D. at
[email protected] or 301-496-3376.
[[Page 13354]]
Silica-Coated Nanodiamonds for Imaging and the Delivery of Therapeutic
Agents
Description of Technology: NIH investigators invented a robust and
easily implemented method of synthesizing silica-coated nanodiamonds
for imaging and therapeutic applications. A patent estate covering
these methods is offered for licensing to commercial entities. The
method generally includes coating nanodiamonds with a silica precursor,
e.g., tetraethylorthosilicate (TEOS), inside liposomes. The liposomes
are then removed to yield a final product that is stable, monodisperse,
and easy to functionalize.
Potential Commercial Applications:
Imaging
Drug delivery
Competitive Advantages:
Small size
Physiologically inert carrier
Monodisperse
Stable in aqueous solution
Readily functionalized
Development Stage: Prototype.
Inventors: Ambika Bumb (NHLBI), Susanta Kumar Sarkar (NHLBI), Keir
Neuman (NHLBI), Martin Brechbiel (NCI).
Publications:
1. Yu SJ, et al. Bright fluorescent nanodiamonds: no photobleaching
and low cytotoxicity. J Am Chem Soc. 2005 Dec 21;127(50):17604-5.
[PMID 16351080]
2. Wilson RM. Nanodiamonds are promising quantum probes of living
cells. Phys Today 2011 Aug;64(8):17. [doi 10.1063/PT.3.1204]
3. Chow EK, et al. Nanodiamond therapeutic delivery agents mediate
enhanced chemoresistant tumor treatment. Sci Transl Med. 2011 Mar
9;3(73):73ra21. [PMID 21389265]
4. Krueger A. New carbon materials: biological applications of
functionalized nanodiamond materials. Chemistry 2008;14(5):1382-90.
[PMID 18033700]
Intellectual Property: HHS Reference No. E-175-2012/0--US
Provisional Application No. 61/672,996 filed 18 Jul 2012.
Related Technology: HHS Reference No. E-261-2012/0--US Provisional
Application No. 61/711,702 filed 09 Oct 2012, ``Imaging Methods and
Computer-Readable Media for Background-Free imaging of Fluorescent
Nanodiamonds.''
Licensing Contact: Michael Shmilovich; 301-435-5019;
[email protected].
Collaborative Research Opportunity: The NHLBI Laboratory of Single
Molecule Biophysics is seeking statements of capability or interest
from parties interested in collaborative research to further develop,
evaluate or commercialize fluorescent nanodiamonds for use as in vivo
and in vitro optical tracking probes. For collaboration opportunities,
please contact Keir C. Neuman, Ph.D. at [email protected] or 301-
496-3376.
Dated February 20, 2013.
Richard U. Rodriguez,
Director, Division of Technology Development and Transfer, Office of
Technology Transfer, National Institutes of Health.
[FR Doc. 2013-04443 Filed 2-26-13; 8:45 am]
BILLING CODE 4140-01-P