[Federal Register Volume 79, Number 49 (Thursday, March 13, 2014)]
[Notices]
[Pages 14257-14259]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 2014-05472]
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DEPARTMENT OF HEALTH AND HUMAN SERVICES
National Institutes of Health
Government-Owned Inventions; Availability for Licensing
AGENCY: National Institutes of Health, HHS.
ACTION: Notice.
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SUMMARY: The inventions listed below are owned by an agency of the U.S.
Government and are available for licensing in the U.S. in accordance
with 35 U.S.C. 209 and 37 CFR part 404 to achieve expeditious
commercialization of results of federally-funded research and
development. Foreign patent applications are filed on selected
inventions to extend market coverage for companies and may also be
available for licensing.
FOR FURTHER INFORMATION CONTACT: Licensing information and copies of
the U.S. patent applications listed below may be obtained by writing to
the indicated licensing contact at the Office of Technology Transfer,
National Institutes of Health, 6011 Executive Boulevard, Suite 325,
Rockville, Maryland 20852-3804; telephone: 301-496-7057; fax: 301-402-
0220. A signed Confidential Disclosure Agreement will be required to
receive copies of the patent applications.
Rabies Vaccine for the Oral Immunization of Domesticated Animals,
Wildlife and Feral Animals
Description of Technology: This invention, developed by the CDC and
collaborators, entails a live, attenuated recombinant rabies virus
vaccine that can elicit an effective anti-rabies immune response in
animal recipients. Inoculation with a live, attenuated, rabies virus
allows for the optimized production of immunity in the absence of
pathogenicity. Oral administration of rabies vaccines is often a
preferred route of vaccine delivery because it is most effective in
wildlife. Unfortunately, availability of an oral vaccine for canines
has been a significant hurdle to date.
This vaccine technology could be used for immunization of stray
dogs by an oral route. In developing nations, more than 90% of human
exposure events and 99% of human deaths due to rabies are caused by
rabid dogs. Using this vaccine with a broadly implemented oral
vaccination strategy provides a promising opportunity for reducing
transmission of rabies between stray dogs and, thereby, increasing
protection for people.
Potential Commercial Applications:
Wildlife and humane shelter rabies prevention and control
programs
Improved rabies vaccines for pets and livestock
Humane, targeted approach to elimination of rabies reservoirs
in feral animal populations
Competitive Advantages:
Safe and effective
Oral immunization is the most practical and efficient method
of rabies vaccination of wildlife and feral animals
Vaccine has demonstrated protection in vivo
Recombinant, non-neuroinvasive virus expressing a
neuroinvasive glycoprotein and/or pro-apoptotis gene safely induces a
robust and desirable immunological response
Development Stage:
In vitro data available
In vivo data available (animal)
Inventors: Charles E. Rupprecht (CDC), et al.
Intellectual Property: HHS Reference No. E-470-2013/0--U.S. Patent
No. 7,074,413 issued 11 Jul 2006.
Licensing Contact: Whitney Blair, J.D., M.P.H.; 301-435-4937;
[email protected].
Cable-Line Safety System: Electro/Hydraulic Emergency Stop Device for a
Winch, Drum or Capstan
Description of Technology: This CDC-developed invention entails a
system of electrical and hydraulic circuits used to stop a rotating
winch in an emergency. Amongst other locations, one stop switch can be
positioned on a capstan winch horn. This location makes it available to
a victim entangled in rope being retrieved on a gypsy drum. As
designed, the stop circuit could be used with an electrically,
hydraulically or pneumatically operated winch. A variant of this safety
system has been successfully tested on a purse seining fishing vessel
in Alaskan waters.
Potential Commercial Applications:
Retrofitting existing winches for additional safety and
adherence to possible future regulations
Specifically designed and tested for the marine/fishing
industries
Applications in mining, construction, forestry, and/or off-
road automotive industries
Workers' well-being concern groups
Insurers of fishing vessels; also mining, construction and
forestry operations
Manufacturers of cable reel trailers and wire-drawing
machinery
Competitive Advantages:
[[Page 14258]]
Complies with numerous international safety regulations
requiring winches, drums and capstans to have a master on/off switch in
easy reach for worker safety
Can be packaged as a `retrofit kit' for integration with
current commercial winch/drum usage
Development Stage:
In situ data available (on-site)
Prototype
Inventors: Chelsea Woodward, Todd Ruff, Curtis Clark, Robert
McKibbin, John Bevan, Greg Miller, Wayne Howie, Louis Martin, Jennifer
Lincoln (all inventors from CDC-NIOSH).
Intellectual Property: HHS Reference No. E-355-2013/0--Research
Tool. Patent protection is not being pursued for this technology.
Related Technologies:
HHS Reference No. E-504-2013/0
HHS Reference No. E-567-2013/0
HHS Reference No. E-568-2013/0
HHS Reference No. E-643-2013/0
Licensing Contact: Whitney Blair, J.D., M.P.H.; 301-435-4937;
[email protected].
Lead Detection Wipes for Potentially Contaminated Surfaces
Description of Technology: This CDC-developed invention relates to
a method for the detection of lead on surfaces (such as, for example,
skin, floors, walls, windows sills) using a `handwipe' system and a
chemical test effecting a characteristic color change if contaminating
lead is present. This invention is especially useful in detecting the
presence of lead on skin and assessing the effectiveness of hand
washing in removal of lead from the skin of exposed individuals.
Further, this invention is useful in field evaluation for the presence
of lead, exposure of individuals to lead, and the effectiveness of its
subsequent removal in the workplace, home, school, and similar
environments.
Potential Commercial Applications:
Suitable for lead-testing surfaces such as floors, walls,
windowsills and human skin
Evaluation of lead-removal effectiveness from surfaces in
homes, hospitals, workplaces and schools
Confirming hand/skin/shoe/clothing-washing effectiveness of
lead removal for military, target range personnel
Competitive Advantages:
Simple color-change readout indicates the presence of lead on
a surface
Rapid test; lead concentration can be inferred by degree of
color shift
Safe for use on skin
Development Stage:
In vitro data available
In situ data available (on-site)
Inventors: Eric J. Esswein, Mark F. Boeniger, Kevin E. Ashley (all
of CDC).
Publications:
1. Ashley K. Field-portable methods for monitoring occupational
exposures to metals. J Chem Health Saf. 2010;17(3):22-8. [http://dx.doi.org/10.1016/j.jchas.2009.07.002]
2. NIOSH Manual of Analytical Methods (NMAM), Fourth Edition. Method
9105, Issue 1--Lead in Dust Wipes by Chemical Spot Test Method
(Colorimetric Screening Method), 15 March 2003. U.S. National
Institute for Occupational Safety and Health (NIOSH), Cincinnati,
OH. [http://www.cdc.gov/niosh/docs/2003-154/pdfs/9105.pdf ]
3. Esswein EJ, et al. Handwipe Method for Removing Lead from
Skin. Journal of ASTM International. 2011 May;8(5):Paper ID
JAI103527. [http://dx.doi.org/10.1520/JAI103527]
Intellectual Property: HHS Reference No. E-336-2013/0--U.S. Patent
No. 6,248,593 issued 19 Jun 2001.
Related Technology:
HHS Reference No. E-356-2013/0
HHS Reference No. E-359-2013/0
Licensing Contact: Whitney Blair, J.D., M.P.H.; 301-435-4937;
[email protected].
Mining Safety: Personal Dust Monitor Filters for Accurate, Quantifiable
Spectrometric Analysis and Assessment of Worker Exposure Levels
Description of Technology: This CDC-developed invention pertains to
a novel dust monitor filter that is specially constructed of organic
materials for spectrometric analysis, ultimately allowing for detection
and accurate quantification of a particular chosen analyte (e.g.,
crystalline silica/quartz dust that may lead to silicosis).
For miners, the risk of lung disease increases with the extent of
dust exposure, and coal worker's pneumoconiosis (aka, black lung
disease) and silicosis are still dangers routinely faced by those in
the industry. Expectedly, both the concentration and the composition of
airborne particulate matter present in mining environments are points
of regulatory concern. For some time, collecting airborne dust samples
and subsequent determination of quartz content have been integral for
assessing mine worker exposure and demonstrating compliance with US
Federal regulations.
Unfortunately, highly accurate spectrometric detection and
quantification of particulate exposure has not always been possible.
Generally, the filters used in existing oscillating microbalances (such
as the TEOM[supreg] monitor) have been specially designed to for
hydrophobicity, in order to retain as little moisture as possible on
the filter. These specialized hydrophobic filters (and/or their
mounting components) contain inorganic compounds that cannot be readily
subjected to thermal or chemical destruction--a necessary first step of
many instrumental analytical methods, such as spectroscopy.
This CDC-developed filter consists of entirely ashable material,
making it ideal for spectrometric analysis and rapid exposure
assessment. As an example, this dust monitor filter can be made
entirely of organic materials and designed for quick, easy ashing that
will not produce interference with the spectroscopic characteristics of
the chosen analyte(s). Further, filter ashing can be carried out by a
variety of methods: thermal ashing, microwave ashing, low temperature
ashing, or chemical destruction.
Potential Commercial Applications:
Personal dust monitors worn wherever dust exposure levels and
the presence of potentially injurious materials is evaluated
Occupationally-mandated pneumoconiosis, asbestosis and/or
silicosis prevention and monitoring programs, for complying with safety
regulations
Miners' wellness concern groups and insurance companies
Competitive Advantages:
Novel dust-monitoring instrument capable of providing near
rapid particulate exposure information to miners/users
Improves upon older technology by allowing for accurate
detection and quantification of chosen analyte(s) and, unlike other
filters, does not produce overlap or interfere with spectroscopic
analysis
Filter can be easily ashed for analysis by thermal ashing,
microwave ashing, low temperature ashing, or chemical destruction
Development Stage:
Early-stage
In vitro data available
Publication:
Tuchman DP. Implementing infrared determination of quartz
particulates on novel filters for a prototype dust monitor. J
Environ Monit. 2008 May;10(5):671-8. [PMID 18449405]
Intellectual Property: HHS Reference No. E-312-2013/0--U.S. Patent
No. 7,947,503 issued 24 May 2011.
Licensing Contact: Whitney Blair, J.D., M.P.H.; 301-435-4937;
[email protected].
[[Page 14259]]
Computer Controlled Aerosol Generator With Multi-Walled Carbon Nanotube
Inhalation Testing Capabilities
Description of Technology: This invention pertains to a CDC-NIOSH
developed sonic aerosol generator that provides a controllable, stable
concentration of particulate aerosol over a long period of time for
aerosol exposure studies. Specifically, in situ testing data indicate
uniform aerosol stability can be maintainable for greater than 30 hours
at concentrations of 15 mg/m3 or more. Additionally, the technology was
specifically developed for, and validated in, animal studies assessing
exposure to airborne multi-walled carbon nanotubes (MWCNT). It has been
suggested that workers may be at risk for exposure to nanosized
particles during the manufacture, handling, and cleanup of engineered
nanomaterials. Compared to other technologies, this NIOSH aerosol
generator is particularly helpful when used for generating high testing
concentrations of MWCNT aerosols that more accurately represent
particulate levels that may be seen in a workplace environment.
Potential Commercial Applications:
Studying the size and shape of the aerosolized particles
produced from simple vibrations of bulk material
Toxicological investigations and risk assessment of aerosol
exposures, especially those related to nanoparticle manufacturing.
Any aerosolization application where the aggregating ``bird's
nest'' tendencies of airborne multi-walled carbon nanotubes must be
overcome
Competitive Advantages:
Fully automated system with integrated feedback control for
optimized stability in testing
Maintains concentration of aerosols for >30 hours at
concentrations of 15 mg/cubic meter or more
Capable of generating high concentrations of aerosols that
more accurately represent the levels seen in a workplace environment
System insures that each run produces a constant particle
concentration, air flow, pressure, temperature and humidity within a
testing chamber
Development Stage:
In vitro data available
In vivo data available (animal)
In situ data available (on-site)
Prototype
Inventors: Walter G. McKinney, David G. Frazer, Bean Chen (all of
CDC)
Publications:
1. McKinney W, et al. Computer controlled multi-walled carbon
nanotube inhalation exposure system. Inhal Toxicol. 2009
Oct;21(12):1053-61. [PMID 19555230]
2. Porter DW, et al. Acute pulmonary dose-responses to inhaled
multi-walled carbon nanotubes. Nanotoxicology. 2013 Nov;7:1179-94.
[PMID 22881873]
3. Porter DW, et al. Mouse pulmonary dose- and time course-responses
induced by exposure to multi-walled carbon nanotubes. Toxicology.
2010 Mar 10;269(2-3):136-47. [PMID 19857541]
4. Chen BT, et al. Multi-walled carbon nanotubes: sampling criteria
and aerosol characterization. Inhal Toxicol. 2012 Oct;24(12):798-
820. [PMID 23033994]
Intellectual Property: HHS Reference No. E-156-2013/0--U.S. Patent
Application No. 12/871,453 filed 30 Aug 2010.
Licensing Contact: Whitney Blair, J.D., M.P.H.; 301-435-4937;
[email protected].
Dated: March 10, 2014.
Richard U. Rodriguez,
Director, Division of Technology Development and Transfer, Office of
Technology Transfer, National Institutes of Health.
[FR Doc. 2014-05472 Filed 3-12-14; 8:45 am]
BILLING CODE 4140-01-P