[Federal Register Volume 80, Number 245 (Tuesday, December 22, 2015)]
[Notices]
[Page 79594]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 2015-32096]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

National Institutes of Health


Government-Owned Inventions; Availability for Licensing

AGENCY: National Institutes of Health, HHS.

ACTION: Notice

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SUMMARY: The inventions listed below are owned by an agency of the U.S. 
Government and are available for licensing in the U.S. in accordance 
with 35 U.S.C. 209 and 37 CFR part 404 to achieve expeditious 
commercialization of results of federally-funded research and 
development. Foreign patent applications are filed on selected 
inventions to extend market coverage for companies and may also be 
available for licensing.

FOR FURTHER INFORMATION CONTACT: Licensing information and copies of 
the U.S. patent applications listed below may be obtained by emailing 
the indicated licensing contact at the National Heart, Lung, and Blood, 
Office of Technology Transfer and Development Office of Technology 
Transfer, 31 Center Drive Room 4A29, MSC2479, Bethesda, MD 20892-2479; 
telephone: 301-402-5579. A signed Confidential Disclosure Agreement may 
be required to receive copies of the patent applications.

SUPPLEMENTARY INFORMATION: Technology description follows.

Metallic Nanoparticles for Photothermal Therapy

    Description of Technology: The invention relates to the preparation 
and application of 20-150nm metallic nanoparticulate vesicles for 
photothermal anti-cancer therapy. The vesicles comprise metallic 
nanoparticles covalently bound to a hydrophilic and hydrophobic 
polymer. The preparation method generally entails dispersing a polymer-
bound metallic nanoparticle in an organic solvent, adding an aqueous 
solution with a dispersing aid, sonicating the mixture, and finally 
removing the organic solvent until the vesicle forms. The final vesicle 
is stable wherein the metallic nanoparticle is covalently bound to the 
hydrophobic and hydrophilic polymer. By way of a non-limiting example, 
an exemplary vesicles can be one made from gold nanorods coated with 
polyethylene glycol and polylactic-co-glycolic acid (AuNR@PEG/PLGA) in 
an oil-in-water emulsion.

    Potential Commercial Applications:

 Cancer therapy
 Tumor therapy

    Competitive Advantages:

 Prolonged circulation
 High tumor accumulation
 Rapid excretion
 Enhanced photoacoustic signal
 Enhanced photothermal effect/cancer therapy efficacy.

    Development Stage:

 In vitro data

    Inventors: Xiaoyuan (Shawn) Chen and Jibin Song (both of NIBIB).
    Intellectual Property: HHS Reference No. E-158-2015/0-US-01.
     U.S. Provisional Patent Application 62/226,289 filed 
December 11, 2015.
    Licensing Contact: Michael Shmilovich, Esq, CLP; 301-435-5019; 
[email protected].
    Collaborative Research Opportunity: The National Institute of 
Biomedical Imaging and Bioengineering seeks statements of capability or 
interest from parties interested in collaborative research to further 
develop and evaluate metallic nanoparticle vesicles for cancer 
phototherapy. For collaboration opportunities, please contact Cecilia 
Pazman, Ph.D. at [email protected].

    Dated: December 15, 2015.
Michael Shmilovich,
Senior Licensing and Patenting Manager, National Heart, Lung, and Blood 
Institute, Office of Technology Transfer and Development.
[FR Doc. 2015-32096 Filed 12-21-15; 8:45 am]
 BILLING CODE 4140-01-P