[Federal Register Volume 81, Number 126 (Thursday, June 30, 2016)]
[Notices]
[Page 42719]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 2016-15441]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

National Institutes of Health


Government-Owned Inventions; Availability for Licensing

AGENCY: National Institutes of Health, HHS.

ACTION: Notice.

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SUMMARY: The inventions listed below are owned by an agency of the U.S. 
Government and are available for licensing in the U.S. in accordance 
with 35 U.S.C. 209 and 37 CFR part 404 to achieve expeditious 
commercialization of results of federally-funded research and 
development.

FOR FURTHER INFORMATION CONTACT: Licensing information may be obtained 
by emailing the indicated licensing contact at the National Heart, 
Lung, and Blood, Office of Technology Transfer and Development Office 
of Technology Transfer, 31 Center Drive Room 4A29, MSC2479, Bethesda, 
MD 20892-2479; telephone: 301-402-5579. A signed Confidential 
Disclosure Agreement may be required to receive any unpublished 
information.

SUPPLEMENTARY INFORMATION: Technology description follows.

Multi-Photon Microscopy System Configured for Multiview Non-Linear 
Optical Imaging

    This invention is a microscopy device and system for multi-photon 
microscopy utilizing multi-view nonlinear optical imaging. Nonlinear 
optical imaging remains the premier technique for deep-tissue imaging 
in which typically a multi photon arrangement may be used to illuminate 
and excite a sample. However, the penetration depth, signal-to-noise 
ratio, and resolution of this technique is ultimately limited by 
scattering. The present system addresses these issues by sequential 
excitation of a sample through three or more objective lenses oriented 
at different axes intersecting the sample. Each objective lens is 
capable of focused sequential excitation that elicits fluorescence 
emissions from the excited sample, which is then simultaneously 
detected by each respective objective lens along a respective 
longitudinal axis. Including multiple lenses will improve the 
penetration depth and at the same time decrease the loss of detail 
because of scattering. The system also can overcome losses in spatial 
resolution because of the scattering of the excitation and emission 
light.

Potential Commercial Applications:
    --High resolution multi-photon microscopy
    --Deep tissue visualization
--Competitive Advantages:
    --Improved signal-to-noise ratio
    --improved spatial resolution
--Development Stage:
     Prototype

    Inventors: Yicong Wu (NIBIB), Hari Shroff (NIBIB), Jianyong Tang 
(NIAID), Ronald Germain (NIAID).
    Intellectual Property: HHS Reference No. E-229-2015/0; U.S. 
Provisional Patent Application 62/210,153 filed August 26, 2015.
    Licensing Contact: Michael Shmilovich, Esq, CLP; 301-435-5019; 
[email protected].

    Dated: June 24, 2016.
Michael Shmilovich,
Senior Licensing and Patenting Manager, National Heart, Lung, and Blood 
Institute, Office of Technology Transfer and Development.
[FR Doc. 2016-15441 Filed 6-29-16; 8:45 am]
 BILLING CODE 4140-01-P