[Federal Register Volume 81, Number 217 (Wednesday, November 9, 2016)]
[Notices]
[Pages 78792-78793]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 2016-26995]
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DEPARTMENT OF COMMERCE
National Institute of Standards and Technology
Notice of Availability for Licensing--NIST's Patented
Microfluidic Apparatus and Method To Control Liposome Formation
AGENCY: National Institute of Standards and Technology.
ACTION: Notice.
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SUMMARY: The National Institute of Standards and Technology (NIST), an
agency of the United States Department of Commerce, owns two patents
related to controlled liposome formation using microfluidic channels:
U.S. Patent
[[Page 78793]]
9,198,645, titled ``Controlled Vesicle Self-Assembly in Continuous Two
Phase Flow Microfluidic Channels'' (NIST Docket 04-003); and U.S.
Patent 8,715,591, title ``Microfluidic Apparatus to Control Liposome
Formation'' (NIST Docket 09-017). Further details about these patents
are provided in the SUPPLEMENTARY INFORMATION section, below.
ADDRESSES: For further information about these patented inventions or
other licensing and partnership opportunities, please contact Honeyeh
Zube, CRADA and License Officer, National Institute of Standards and
Technology's Technology Partnerships Office, by mail to 100 Bureau
Drive, Mail Stop 2200, Gaithersburg, Maryland 20899, by electronic mail
to [email protected], or by telephone at (301) 975-2209.
SUPPLEMENTARY INFORMATION: NIST's Patent 9,198,645, titled ``Controlled
Vesicle Self-Assembly in Continuous Two Phase Flow Microfluidic
Channels'' (NIST Docket 04-003) claims novel methods for the formation
of liposomes that encapsulate reagents in a continuous two-phase flow
microfluidic network with precision control of size, for example, from
100 nm to 300 nm, by manipulation of liquid flow rates are described.
By creating a solvent-aqueous interfacial region in a microfluidic
format that is homogenous and controllable on the length scale of a
liposome, fine control of liposome size and polydispersity can be
achieved.
NIST's Patent 8,715,591, title ``Microfluidic Apparatus to Control
Liposome Formation,'' (NIST Docket 09-017) is available for license and
claims the apparatus and method of using a microfluidic device that
controls the amount of delivery compound incorporated in a liposome on
a nanometer size scale using laminar flow and miscible fluids, thereby
increasing loading efficiency. The patent was filed on Apr. 19, 2010
and was issued on May 6, 2014. The invention was first published in
Jahn, et al., Microfluidic Directed Formation of Liposomes of
Controlled Size, American Chemical Society Langmuir, 23 (11) pp 6289-
6293. 2007.
The liposomes formed by the self-assembly process are characterized
using asymmetric flow field-flow fractionation combined with quasi-
elastic light scattering and multiangle laser-light scattering. The
vesicle size and size distribution are tunable over a mean diameter
from 50 to 150 nm by adjusting the ratio of the alcohol-to-aqueous
volumetric flow rate. Liposome formation depends more strongly on the
focused alcohol stream width and its diffusive mixing with the aqueous
stream than on the sheer forces at the solvent-buffer interface. The
inventions have application in drug delivery, gene therapy, and
potential application for on-demand liposome-mediated delivery of
point-of-care therapeutics. The inventions can obviate the need for
post-processing in drug manufacturing.
NIST is authorized to license its rights in these inventions to
organizations on a non-exclusive or exclusive basis for specified
fields of use. The rights to these patents are available for exclusive
or non-exclusive licensing by the authority granted to the NIST under
35 U.S.C. 209 and 37 CFR 404. NIST researchers are interested in
potential collaborations with licensees to bring this invention to
practical application and to promote innovation, enhance economic
security and improve quality of life.
Kevin Kimball,
Chief of Staff.
[FR Doc. 2016-26995 Filed 11-8-16; 8:45 am]
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