[Federal Register Volume 81, Number 220 (Tuesday, November 15, 2016)]
[Notices]
[Page 80082]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 2016-27337]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

National Institutes of Health


Government-Owned Inventions; Availability for Licensing

AGENCY: National Institutes of Health, HHS.

ACTION: Notice.

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SUMMARY: The inventions listed below are owned by an agency of the U.S. 
Government and are available for licensing in the U.S. in accordance 
with 35 U.S.C. 209 and 37 CFR part 404 to achieve expeditious 
commercialization of federally-funded research and development. Foreign 
patent applications are filed on selected inventions to extend market 
coverage for companies and may also be available for licensing.

FOR FURTHER INFORMATION CONTACT: Licensing information and copies of 
the U.S. patent applications listed below may be obtained by writing to 
the indicated licensing contact at the National Heart, Lung and Blood 
Institute, Office of Technology Transfer and Development, National 
Institutes of Health, 31 Center Drive Room 4A29, MSC2479, Bethesda, MD 
20892-2479; telephone: 301-402-5579. A signed Confidential Disclosure 
Agreement may be required to receive copies of the patent applications.

SUPPLEMENTARY INFORMATION: Technology descriptions follow.

Immortalized Stria Vascularis Cell Line SV-k1

Description of Technology

    Available for nonexclusive licensing for research uses is the cell 
line, SV-k1, derived from the Organ of Corti. The line was developed 
from the stria vascularis, an organ localized on the lateral wall of 
the cochlea, adjacent to the Organ of Corti, containing cell 
populations specialized in the production of an endolymph very rich in 
K\+\ characteristic of the mammalian inner ear. SV-k1 cells express a 
set of biomarkers completely different of those expressed by OC-k3 
cells (See notice for E-012-2017/0 published contemporaneously 
herewith), and are not sensitive to ototoxic drugs.

Potential Commercial Applications

     Research
     Hearing research

Development Stage

     Materials

Inventors

Gilda Mabel Canseco de Kalinec and Federico Kalinec (both of NIDCD).

Publications

1. Espreafico, EM et al., ``Localization of Myosin-V in the 
Centrosome'' (1998) Proc Nat'l Acad Sci USA 95(15):8636-8641, 1998.
2. Gratton MA et al., ``Strial marginal cells play a role in basement 
membrane homeostasis: In vitro and in vivo evidence.'' Hear Res 163:27-
36, 2002.
3. Park, C., et al., ``HEl-OC1 Cells as a Model for Investigating 
Prestin Function.'' (2016) Hear Res 335:9-17.

Intellectual Property

    HHS Reference No. E-013-2017/0--Research Material.

Licensing Contact

    Michael Shmilovich, Esq, CLP; 301-435-5019; [email protected].

    Dated: November 7, 2016.
Michael Shmilovich,
National Heart, Lung and Blood Institute, Office of Technology Transfer 
and Development, National Institutes of Health.
[FR Doc. 2016-27337 Filed 11-14-16; 8:45 am]
 BILLING CODE 4140-01-P