[Federal Register Volume 59, Number 79 (Monday, April 25, 1994)] [Unknown Section] [Page 0] From the Federal Register Online via the Government Publishing Office [www.gpo.gov] [FR Doc No: 94-9932] [[Page Unknown]] [Federal Register: April 25, 1994] ----------------------------------------------------------------------- DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Government-Owned Inventions; Availability for Licensing AGENCY: National Institutes of Health; HHS. ACTION: Notice. ----------------------------------------------------------------------- The inventions listed below are owned by agencies of the U.S. Government and are available for licensing in the U.S. in accordance with 35 U.S.C. 207 to achieve expeditious commercialization of results of federally funded research and development. Foreign patent applications are filed on selected inventions to extend market coverage for U.S. companies and may also be available for licensing. ADDRESSES: Licensing information and copies of the U.S. patent applications listed below may be obtained by writing to the indicated Licensing Specialist at the Office of Technology Transfer, National Institutes of Health, 6011 Executive Boulevard, suite 325, Rockville, Maryland 20852-3804 (telephone 301/496-7735; fax 301/402-0220). A signed Confidential Disclosure Agreement will be required to receive copies of the patent applications. Issued patents may be obtained from the Commissioner of Patents, U.S. Patent and Trademark Office, Washington, DC 20231. Attenuation of Ethyl Alcohol Intoxication With2 Adrenoceptor Antagonists Linnoila, M., Lister, R., Durcan, M. (NIAAA) Serial No. 07/512,835 (DIV of 07/294,119) U.S. Patent No. 5,109,007 issued 28 Apr 92 Licensing Specialist: Arthur J. Cohn A new method of treating ethyl alcohol intoxication through the use of antagonists for the 2 adrenoceptor has been discovered. Drugs based on these antagonists may have none of the potentially harmful sedative effects of the tranquilizers currently used. 2 adrenoceptor agonists believed useful for this purpose include: atipamexole, idazoxan, imiloxan, yohimbine, Wyeth WY26703, Chinoin CH38083, Glaxo GR50360A, and Daiichi Seiyaku DG5128. Rapid And Sensitive Test For Detecting Hepatitis A Virus Robertson, B.H., Nainan, O.V., Brown, V.K., Margolis, H.S., Khanna, B. (CDC) Filed 31 Jan 92 Serial No. 07/828,444 (CIP of 07/469,143) Licensing Specialist: Girish C. Barua Diagnostic methods with improved sensitivity and specificity to hepatitis A virus (HAV) are needed. This novel assay can be used to test for general HAV infection as well as to differentiate between HAV genotype I, which is thought to be the most common HAV, and HAV genotype II, which differs genetically from HAV I (as well as HAV type III) by about 15%. Free HAV is removed from stool, environmental samples, and other materials by immunoselection of whole virus using high titer anti-HAV antibodies coated onto a solid phase; viral RNA is then denatured in the presence of primers that recognize all known HAV genotypes and that bind to viral RNA for reverse transcription into cDNA. PRC is used to amplify cDNA with Taq polymerase using either labeled or unlabeled primers, depending on whether information on virus type is desired. This novel method is faster and more specific than currently available assays. Production of Isolated Proteinaceous Materials Using Recombinant Avipox Virus Vectors Falkner, F.G., Dorner, F., Bodemer, W., Scheiflinger, F., Moss, B. (NIAID) Filed 11 May 92 Serial No. 07/882,768 (CIP of 07/734,741, CIP of 07/339,738) Licensing Specialist: Girish C. Barua This invention concerns the use of avipox viruses as vectors for the expression of foreign DNA in animal tissue culture. The viruses are constructed in the same convenient manner as recombinant vaccinia viruses, by recombination of a recombinant plasmid with wild type avipox virus. They have an advantage over vaccinia viruses in not being pathogenic for humans or mammals. The recombinant avipox viruses can, however, infect mammalian cell cultures as well as avian cell cultures. Eukaryotic Expression Vector System Giri, C.P., Ogawa, H., Harris, C.C. (NCI) Filed 22 Mar 93 Serial No. 08/034,652 Licensing Specialist: Carl C. Floyd, Ph.D. The method presented here allows for the enrichment of full length cDNAs of genes selected by their phenotypes. This is achieved by providing a vector system capable of synthesizing sense and antisense RNAs in vitro to generate RNA probes for use in an RNA:RNA hybridization based subtraction method. It also provides such an RNA:RNA hybridization based subtraction method for enrichment of the rare cDNs of interest. This will allow the selection of rare human cDNAs, for example, where limited amounts of cells are available. DNA Sequence Which Acts as a Chromatin Insulator Element To Protect Expressed Genes From Cis-Acting Regulatory Sequences Chung, H.J. Felsenfeld, G. (NIDDK) Filed 7 Apr 93 Serial No. 08/045,266 Licensing Specialist: Carl C. Floyd, Ph.D. Novel method of insulating functional DNA domains introduced into higher eukaryotic cells from the effects of the cell's cis-acting regulatory elements. The invention represents the first pure insulator to be demonstrated to function in human cells. The element promises to be a useful tool in gene therapy, gene transfer techniques, and studies involving gene regulation and other gene expression technologies. Peptide Inhibitors of Protein Tyrosine Kinase--SH2 Interactions Roller, P.P. Burke, T.R., Otaka, A., Nomizu, M. (NCI) Filed 8 Jun 93 Serial No. 08/072,946 Licensing Specialist: Carl C. Floyd, Ph.D. The invention relates to synthetic peptides which are inhibitors of protein-protein interactions, specifically that interaction between a protein having a src homology domain (SH2 domain) and a protein having a phosphorylated tyrosine that is recognized by the SH2 domain. This type of interaction occurs during cellular signal transduction cascades. These cascades are central in the regulation of cellular proliferation and therefore their control is of importance to chemotherapeutic approaches to antitumor therapy. Phosphonoalkyl Phenylalanine Compounds Suitably Protected for Use In Peptide Synthesis Burke, T.R., Smyth, M.S., Lim, B.B. (NCI) Filed 8 Jun 93 Serial No. 08/073,088 Licensing Specialist: Carl C. Floyd, Ph.D. Phosphono(difluromethyl)phenylalanine (F2Pmp) is a chemically and enzymatically stable mimetic of phosphotyrosine. The molecule is suitably protected for use in solid-phase peptide synthesis and could be the reagent of choice for synthesis of peptides containing stable phosphotyrosyl mimetics. Three Highly Informative Microsatellite DNA Markers for Use In Human Individualization Merril, C.R., Polymeropoulos, M.H. (NIMH) Filed 9 Jun 93 Serial No. 08/074,275 Licensing Specialist: Carl C. Floyd, Ph.D. The present invention relates to genetic testing with polymorphic DNA markers. The repeat sequences of the markers provide a rapid and convenient high resolution process for distinguishing target nucleic acid segments on the basis of nucleotide differences according to human individualization wherein the nucleic acid segments differ in size. The invention has several applications in the areas of forensic screening, paternity and prenatal screening, as well as genetic mapping. The First Immortalized Kaposi's Sarcoma Cell Line Iskandar-Lunardi, Y.L., Gallo, R.C. (NCI) Filed 20 Aug 93 Serial No. 08/110,175 Licensing Specialist: Carl C. Floyd, Ph.D. Kaposi's Sarcoma (KS) is the most common malignancy in patients with acquired immunodeficiency syndrome (AIDS) in the U.S. The present invention makes available cell lines that provide a means for testing anti-Kaposi's Sarcoma therapies in vitro, or a model animal system. The invention allows therapies to be tested and dosages to be optimized prior to testing in humans. The cell line also provides a means of developing novel antitumor therapies and facilitates studies of factors that influence the development and metastasis of malignancies. The Cloning Of Perilipin Proteins Londos, C., Greenberg, A.S., Kimmel, A.R., Egan, J.J. (NIDDK) Filed 4 Oct 93 Serial No. 08/132,649 Licensing Specialist: Carl C. Floyd, Ph.D. Perilipins are found at the surface of lipid storage droplets of adipocytes. Little is known about the molecules on the surface of lipid droplets that may be involved in lipid metabolism and trafficking. The present invention provides isolated nucleic acid sequences which encode a family of perilipin proteins as well as isolated, purified perilipin proteins. These are useful as markers for differentiation of true adipocyte cells from non-adipocyte cells which, as a result of pathophysiological conditions, assume adipocyte characteristics. Dated: April 11, 1994. Donald P. Christoferson, Acting Director, Office of Technology Transfer. [FR Doc. 94-9932 Filed 4-22-94; 8:45 am] BILLING CODE 4140-01-M