[Federal Register Volume 59, Number 137 (Tuesday, July 19, 1994)] [Unknown Section] [Page 0] From the Federal Register Online via the Government Publishing Office [www.gpo.gov] [FR Doc No: 94-17439] [[Page Unknown]] [Federal Register: July 19, 1994] ----------------------------------------------------------------------- DEPARTMENT OF HEALTH AND HUMAN SERVICES Public Health Service National Toxicology Program; Fiscal Year 1993 Annual Report The National Toxicology Program (NTP) announces the availability of the NTP Annual Plan for Fiscal Year 1993, solicits comments on it, and urges all interested persons to propose chemicals for possible toxicological evaluation. In the interest of accuracy due to the lateness of publication, the fifteenth edition has been titled the NTP Annual Report, and as such it primarily contains program accomplishments for FY 1992. Accomplishments for FY 1993 and program plans for FY 1994 are reported in the FY 1994 Annual Plan (in press). Background The National Toxicology Program (NTP) was established within the Public Health Service of the Department of Health and Human Services (DHHS) in November 1978. The continuing broad goals of the NTP are to coordinate and strengthen DHHS basic and applied toxicology research and methods development and validation, and to provide toxicological information for use by health research and regulatory agencies and others in protecting the public health. Overall objectives are to: Broaden the spectrum of toxicological information obtained on selected chemicals; Increase the numbers of chemicals studied, within funding limits; Develop and validate assays and protocols responsive to regulatory needs; Communicate Program plans and results to governmental agencies, the medical and scientific communities, and the public. The NTP coordinates selected toxicology activities of the National Institute of Environmental Health Sciences, National Institutes of Health; the National Center for Toxicological Research, Food and Drug Administration; and the National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention. Primary program oversight is provided by the NTP Executive Committee, which links DHHS health research institutes and centers with Federal health regulatory agencies to ensure that the basic and applied toxicology research and development activities are responsive to regulatory and public health needs. Agencies represented on the Executive Committee are: Agency for Toxic Substances and Disease Registry Consumer Product Safety Commission Environmental Protection Agency Food and Drug Administration National Cancer Institute National Institute for Occupational Safety and Health National Institute of Environmental Health Sciences National Institutes of Health Occupational Safety and Health Administration The NTP Board of Scientific Counselors provides scientific oversight, advising the NTP Director and the NTP Executive Committee on scientific content and evaluating the scientific merit and overall quality of NTP science. The members (listed in the 1993 Annual Report) are appointed by the Secretary, DHHS. For the purposes of the Program, the NTP Director reports to the Assistant Secretary for Health. Scientific activities are divided into three major program areas: carcinogenesis; genetic toxicology; and toxicologic characterization. The latter area covers activities in cardiac, immunologic, neurobehavioral, respiratory and reproductive and developmental toxicologies, and includes efforts in chemical disposition. There are special programs in studying the toxicities of AIDS therapeutics and the toxicities of Superfund chemicals. Program and project leaders, along with addresses and telephone numbers, are identified in the 1993 Annual Report. The chemical nomination and selection process is integral to the effective long-term operation and success of the NTP with respect to toxicological studies of chemicals using modern techniques and to the development and validation of new assay methods, as well as for use in evaluation of new concepts of mechanisms of toxicity. Thus, the NTP welcomes nominations of chemicals for study from everyone. Especially sought are nominations of chemicals for study of noncancer endpoints. At a minimum, the nominator should give the name of the chemical or substance, the rationale for the nomination, and recommend the type study(s) to be considered. In addition, it is desirable, but not essential, to supplement each nomination with the following information, if known: I. Chemical and physical properties. II. Production, use, occurrence, and analysis data. III. Toxicology information. IV. Chemical disposition and structure-activity relationships. V. Planned or ongoing or recently completed toxicological and environmental studies. To receive the NTP Annual Report for Fiscal Year 1993, please write or telephone the NTP Central Data Management, P.O. Box 12233, MD A0-01, Research Triangle Park, N.C. 27709, (telephone 919/541-3419). Comments on the FY 1993 NTP Annual Report are requested and welcome. These should be addressed to Dr. Larry Hart, National Toxicology Program, P.O. Box 12233, Research Triangle Park, N.C. 27709, (telephone 919/541-3971). Richard Griesemer, Deputy Director, National Toxicology Program. [FR Doc. 94-17439 Filed 7-18-94; 8:45 am] BILLING CODE 4140-01-P