[Federal Register Volume 62, Number 126 (Tuesday, July 1, 1997)] [Notices] [Page 35516] From the Federal Register Online via the Government Publishing Office [www.gpo.gov] [FR Doc No: 97-17199] ----------------------------------------------------------------------- DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Proposed Collection; Comment Request; Mapping Alcoholism Related Genes by Linkage Disequilibrium in Choctaw American Indians With Mixed Ancestry SUMMARY: In compliance with Section 3506(c)(2)(A) of the Paperwork Reduction Act of 1995, which provides for an opportunity for public comment on proposed data collection projects, the National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Institutes of Health (NIH) will publish periodic summaries of proposed projects to be submitted to the Office of Management and Budget (OMB) for review and approval. Proposed Collection The Laboratory of Neurogenetics (LN), Division of Intramural Clinical and Biological Research, NIAAA, intends to conduct the study for `Mapping Alcoholism Related Genes by Linkage Disequilibrium in Choctaw American Indians with Mixed Ancestry'. The LN is authorized by Section 452 of Part G of Title IV of the Public Health Service Act (42 U.S.C. 288) as amended by the NIH Revitalization Act of 1993 (Pub. Law 103-43). The information proposed for collection in this study will be used by the NIAAA to expand the Choctaw Indian study by sampling people and families that exhibit a spectrum of Indian and non-Indian ancestry. This is possible because the Choctaw have approximately 100,000 enrolled members and 95% of them have some degree of non-Indian heritage. It is now recognized that admixed populations are useful for linkage analysis using a variety of techniques, including Mapping using Admixture Linkage Disequilibrium and Transmission Disequilibrium Test. This extension of NIAAA research on Choctaw American Indians will utilize the population structure in a unique way to determine the genetic basis of alcoholism and related psychiatric phenotypes. It will complement the current family and epidemiological approaches. In combination, these different approaches will yield one of the most comprehensive studies yet performed. Moreover, this study recognizes the true population structure and utilizes it to analytical advantage. The annual burden estimates are as follows: ---------------------------------------------------------------------------------------------------------------- Responses Type and number of respondents per Total Hours Total hours respondent responses ---------------------------------------------------------------------------------------------------------------- Clients--700................................................ 1 700 4.0 2800 Total Number of Respondents................................. ........... 700 ........... ........... Total Number of Responses................................... ........... 700 ........... ........... Total Hours................................................. ........... 2800 ........... ........... ---------------------------------------------------------------------------------------------------------------- Request for Comments Comments are invited on: (a) whether the proposed collection is necessary, including whether the information has practical use; (b) ways to enhance the clarity, quality, and use of the information to be collected; (c) the accuracy of the agency estimate of burden of the proposed collection; and (d) ways to minimize the collection burden of the respondents. Send written comments to Ms. Ronni Nelson, Laboratory of Neurogenetics, Division of Intramural Clinical and Biological Research, NIAAA, NIH, Park Bldg. Room 451, 12420 Parklawn Drive MSC 8110, Rockville, Maryland 20852. FOR FURTHER INFORMATION: To request more information on the proposed project or to obtain a copy of the data collection plans, contact Ms. Ronni Nelson, Laboratory of Neurogenetics, Division of Intramural Clinical and Biological Research, NIAAA, Park Bldg. Room 451, 12420 Parklawn Drive MSC 8110, Rockville, Maryland 20852, or call non-toll- free number (301) 443-5781. COMMENTS DUE DATE: Comments regarding this information collection are best assured of having their full effect if received on or before September 2, 1997. Dated: June 23, 1997. Martin K. Trusty, Executive Officer, NIAAA. [FR Doc. 97-17199 Filed 6-30-97; 8:45 am] BILLING CODE 4140-01-M