[Federal Register Volume 62, Number 126 (Tuesday, July 1, 1997)]
[Notices]
[Page 35516]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 97-17199]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

National Institutes of Health


Proposed Collection; Comment Request; Mapping Alcoholism Related 
Genes by Linkage Disequilibrium in Choctaw American Indians With Mixed 
Ancestry

SUMMARY: In compliance with Section 3506(c)(2)(A) of the Paperwork 
Reduction Act of 1995, which provides for an opportunity for public 
comment on proposed data collection projects, the National Institute on 
Alcohol Abuse and Alcoholism (NIAAA), National Institutes of Health 
(NIH) will publish periodic summaries of proposed projects to be 
submitted to the Office of Management and Budget (OMB) for review and 
approval.

Proposed Collection

    The Laboratory of Neurogenetics (LN), Division of Intramural 
Clinical and Biological Research, NIAAA, intends to conduct the study 
for `Mapping Alcoholism Related Genes by Linkage Disequilibrium in 
Choctaw American Indians with Mixed Ancestry'.
    The LN is authorized by Section 452 of Part G of Title IV of the 
Public Health Service Act (42 U.S.C. 288) as amended by the NIH 
Revitalization Act of 1993 (Pub. Law 103-43). The information proposed 
for collection in this study will be used by the NIAAA to expand the 
Choctaw Indian study by sampling people and families that exhibit a 
spectrum of Indian and non-Indian ancestry. This is possible because 
the Choctaw have approximately 100,000 enrolled members and 95% of them 
have some degree of non-Indian heritage. It is now recognized that 
admixed populations are useful for linkage analysis using a variety of 
techniques, including Mapping using Admixture Linkage Disequilibrium 
and Transmission Disequilibrium Test. This extension of NIAAA research 
on Choctaw American Indians will utilize the population structure in a 
unique way to determine the genetic basis of alcoholism and related 
psychiatric phenotypes. It will complement the current family and 
epidemiological approaches. In combination, these different approaches 
will yield one of the most comprehensive studies yet performed. 
Moreover, this study recognizes the true population structure and 
utilizes it to analytical advantage.
    The annual burden estimates are as follows:

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                                                               Responses                                        
               Type and number of respondents                     per         Total        Hours     Total hours
                                                               respondent   responses                           
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Clients--700................................................            1          700          4.0         2800
Total Number of Respondents.................................  ...........          700  ...........  ...........
Total Number of Responses...................................  ...........          700  ...........  ...........
Total Hours.................................................  ...........         2800  ...........  ...........
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Request for Comments

    Comments are invited on: (a) whether the proposed collection is 
necessary, including whether the information has practical use; (b) 
ways to enhance the clarity, quality, and use of the information to be 
collected; (c) the accuracy of the agency estimate of burden of the 
proposed collection; and (d) ways to minimize the collection burden of 
the respondents. Send written comments to Ms. Ronni Nelson, Laboratory 
of Neurogenetics, Division of Intramural Clinical and Biological 
Research, NIAAA, NIH, Park Bldg. Room 451, 12420 Parklawn Drive MSC 
8110, Rockville, Maryland 20852.

FOR FURTHER INFORMATION: To request more information on the proposed 
project or to obtain a copy of the data collection plans, contact Ms. 
Ronni Nelson, Laboratory of Neurogenetics, Division of Intramural 
Clinical and Biological Research, NIAAA, Park Bldg. Room 451, 12420 
Parklawn Drive MSC 8110, Rockville, Maryland 20852, or call non-toll-
free number (301) 443-5781.

COMMENTS DUE DATE: Comments regarding this information collection are 
best assured of having their full effect if received on or before 
September 2, 1997.

    Dated: June 23, 1997.
Martin K. Trusty,
Executive Officer, NIAAA.
[FR Doc. 97-17199 Filed 6-30-97; 8:45 am]
BILLING CODE 4140-01-M