[Federal Register Volume 63, Number 93 (Thursday, May 14, 1998)] [Notices] [Pages 26818-26820] From the Federal Register Online via the Government Publishing Office [www.gpo.gov] [FR Doc No: 98-12779] ----------------------------------------------------------------------- DEPARTMENT OF HEALTH AND HUMAN SERVICES Public Health Service National Toxicology Program; Availability of the Report on Carcinogens, Eighth Edition Background The National Toxicology Program (NTP) announces the availability of the Report on Carcinogens, Eighth Edition. [[Page 26819]] The Report on Carcinogens (RoC) is a Congressionally-mandated listing of known human carcinogens and reasonably anticipated human carcinogens and its preparation is delegated to the National Toxicology Program by the Secretary, Department of Health and Human Services (HHS). Section 301(b)(4) of the Public Health Service Act, as amended, provides that the Secretary, (HHS), shall publish a report which contains a list of all substances (1) which either are known to be human carcinogens or may reasonably be anticipated to be human carcinogens; and (2) to which a significant number of persons residing in the United States (US) are exposed. The law also states that the reports should provide available information on the nature of exposures, the estimated number of persons exposed and the extent to which the implementation of Federal regulations decreases the risk to public health from exposure to these chemicals. The new entries for the 8th RoC have undergone a multiphased peer review process involving two Federal scientific review groups and one non-government, scientific peer review body (a subcommittee of the NTP Board of Scientific Counselors) which met in an open, public meeting that included a public comment session. All data relevant to the criteria for inclusion of candidate agents, substances or mixtures in the RoC have been evaluated by the three scientific review committees. In the 8th RoC, the NTP is adding 14 agents, substances or mixtures to the existing list. In addition, thiotepa, which is currently listed in previous Reports on Carcinogens as reasonably anticipated to be a human carcinogen is moved to the known human carcinogen list. These agents, substances or mixtures are provided in the following table with their Chemical Abstracts Services (CAS) Registry numbers and listing. Hard copies of the 8th RoC, or the 8th RoC Summary (which contains the same information that is in the full Report with the exception of specific information on regulations promulgated by regulatory health agencies) can be obtained by contacting the NIEHS Environmental Health Information Service, ATTN: Order Processing, P.O. Box 12510, Research Triangle Park, NC 27709-2510, fax number (919) 541-0763, email: [email protected]. The 8th RoC Summary is also available on the internet and can be accessed from the NIEHS Environmental Health Information Service Home Page at: http:///ehis.niehs.nih.gov/ or from the NTP Home Page at: http://ntp-server.niehs.nih.gov//. Questions or comments concerning the 8th RoC should be directed to: Dr. C.W. Jameson, National Toxicology Program, Report on Carcinogens, MD EC-14, P.O. Box 12233, Research Triangle Park, NC 27709; phone: (919) 541-4096, fax: (919) 541-2242, email: [email protected]. Kenneth Olden, Director, National Toxicology Program. Summary for Agents, Substances or Mixtures Newly Listed in the Report on Carcinogens, Eighth Edition ---------------------------------------------------------------------------------------------------------------- Chemical/CAS number Primary uses Newly listed as ---------------------------------------------------------------------------------------------------------------- AZACITIDINE/320-67-2............... Used as a cytostatic agent in the treatment of Reasonably Anticipated to acute leukemia. be a Human Carcinogen p-CHLORO-o-TOLUIDINE and its HCl Used to produce azo dyes for cotton, silk Reasonably Anticipated to salt/95-69-2. acetate and nylon and as intermediate in be a Human Carcinogen. production of Pigment Red 7 and Pigment Yellow 49. Also an impurity in and a metabolite of the pesticide chlordimeform. CHLOROZOTOCIN/54749-90-5........... Used as a cytostatic agent in the treatment of Reasonably Anticipated to cancers of the stomach, large intestine be a Human Carcinogen. pancreas and lung; melanoma; and multiple myeloma. CYCLOSPORIN/59865-13-3............. Used as an immunosuppressive agent in the Known to be a Human prevention and treatment of graft-vs-host Carcinogen. reactions in bone marrow transplantation and for the prevention of rejection of kidney, heart, and liver transplants. DANTHRON/(1,8- Used as a laxative and as an intermediate in Reasonably Anticipated to Dihydroxyanthraquinone) 117-10-2. the manufacture of dyes. be a Human Carcinogen 1,6-DINITROPYRENE/42397-64-8....... Not used commercially, detected in ambient Reasonably Anticipated to atmospheric samples and as a constituent of be a Human Carcinogen diesel exhaust. 1,8-DINITROPYRENE/42397-65-9....... Not used commercially, detected in ambient Reasonably Anticipated to atmospheric samples and as a constituent of be a Human Carcinogen diesel exhaust. DISPERSE BLUE 1/(1,4,5,8- Used as an anthraquinone based dyestuff in hair Reasonably Anticipated to Tetraaminoanthraquinone) 2475-45-8. color formulations and in coloring fabrics and be a Human Carcinogen plastics. FURAN/100-00-9..................... Used as an intermediate in the synthesis and Reasonably Anticipated to production of other organic compounds. be a Human Carcinogen O-NITROANISOLE/91-23-6............. Used a a precursor in the synthesis of o- Reasonably Anticipated to anisidine which is used in the manufacture of be a Human Carcinogen. over 100 azo dyes. 6-NITROCHRYSENE/7495-02-8.......... Not used commercially, detected in ambient Reasonably Anticipated to atmospheric samples. be a Human Carcinogen. 1-NITROPYRENE/5522-43-0............ Not used commercially, detected in ambient Reasonably Anticipated to atmospheric samples and as a constituent of be a Human Carcinogen. diesel and gasoline engine exhaust. 4-NITROPYRENE/57835-92-4........... Not used commercially, detected in ambient Reasonably Anticipated to atmospheric samples. be a Human Carcinogen. THIOTEPA/52-24-4................... Used as a cytostatic agent in the treatment of Known to be a Human lymphomas and a variety of solid tumors, such Carcinogen. as breast and ovary. It has also been used at high doses in combination chemotherapy with cyclophosphamide in patients with refractory malignancies treated with autologous bone transplantation. [[Page 26820]] 1,2,3-TRICHLOROPROPANE/96-18-4..... Used as a polymer crosslinking agent, paint and Reasonably Anticipated to varnish remover, solvent and degreasing agent. be a Human Carcinogen. It has been found as an impurity in certain nematicides and soil fumigants and has been detected in drinking and ground water in various parts of the United States. ---------------------------------------------------------------------------------------------------------------- [FR Doc. 98-12779 Filed 5-13-98; 8:45 am] BILLING CODE 4140-01-M