[Federal Register Volume 78, Number 14 (Tuesday, January 22, 2013)]
[Pages 4419-4421]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 2013-01242]



National Institutes of Health

Draft Report on Carcinogens Monographs for 1-Bromopropane and 
Cumene; Availability of Documents; Request for Comments; Notice of 

SUMMARY: Peer review meeting of the Draft Report on Carcinogens (RoC) 
Monographs for 1-Bromopropane and Cumene. These documents were prepared 
by the Office of the Report on Carcinogens (ORoC), Division of the 
National Toxicology Program (DNTP), National Institute of Environmental 
Health Sciences (NIEHS).

DATES: Meeting: March 21, 2013, 1:00 p.m. to approximately 5:00 p.m. 
Eastern Daylight Time (EDT) and March 22, 2013, from 8:30 a.m. until 
adjournment, approximately 2:00 p.m. EDT.
    Document Availability: Draft monographs will be available by 

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23, 2013, at http://ntp.niehs.nih.gov/go/36639.
    Public Comments Submissions: Deadline is March 7, 2013.
    Pre-Registration for Meeting and/or Oral Comments: Deadline is 
March 19, 2013.

ADDRESSES: Meeting Location: NIEHS, Keystone Building, Room 1003AB, 530 
Davis Drive, Morrisville, NC 27560.
    Agency Meeting Web page: The draft monographs, draft agenda, 
registration and other meeting materials are at http://ntp.niehs.nih.gov/go/36639.
    Webcast: The meeting will be available via webcast at http://www.niehs.nih.gov/news/video/index.cfm.

Federal Official, Office of Liaison, Policy and Review, DNTP, NIEHS, 
P.O. Box 12233, MD K2-03, Research Triangle Park, NC 27709. Phone: 
(919) 541-9834, Fax: (301) 480-3272, Email: whiteld@niehs.nih.gov. Hand 
Delivery/Courier: 530 Davis Drive, Room 2136, Morrisville, NC 27560.

SUPPLEMENTARY INFORMATION: Background: The Report on Carcinogens (RoC) 
is a congressionally mandated, science-based, public health report that 
identifies agents, substances, mixtures, or exposures (collectively 
called ``substances'') in our environment that may put people in the 
United States at increased risk for cancer. The NTP prepares the RoC on 
behalf of the Secretary of Health and Human Services.
    The NTP follows an established, four-part process for preparation 
of the RoC (http://ntp.niehs.nih.gov/go/rocprocess). A RoC Monograph is 
prepared for each candidate substance selected for review for the RoC. 
1-Bromopropane and cumene were selected as candidate substances 
following solicitation of public comment and review by the NTP Board of 
Scientific Counselors review on June 21-22, 2012 (http://ntp.niehs.nih.gov/go/9741). A draft RoC monograph consists of a (1) 
cancer evaluation component that reviews all information that may bear 
on a listing decision, assesses its quality and sufficiency for 
reaching a listing decision, applies the RoC listing criteria to the 
relevant scientific information, and recommends a listing status for 
the candidate substance in the RoC and (2) a substance profile that 
contains the NTP's preliminary listing recommendation and a summary of 
the scientific evidence considered key to reaching that recommendation. 
This meeting is planned for peer review of the draft RoC Monographs for 
1-bromopropane and cumene.
    1-Bromopropane (CASRN 106-94-5) is a brominated hydrocarbon that is 
currently used as a solvent in a variety of industrial and commercial 
applications. It is used as a solvent cleaner to degrease electronics, 
precision optics, and metals, as a solvent vehicle in industries that 
use aerosolized adhesives (e.g., foam cushion manufacturing), as a spot 
remover in the textile industry, and as a solvent in the dry cleaning 
industry. Additional information about the review of 1-bromopropane for 
the RoC is available at http://ntp.niehs.nih.gov/go/37896.
    Cumene (CASRN 98-82-8, isopropylbenzene) is an alkylated benzene 
found in fossil fuels, such as blended gasoline and kerosene, and 
products of incomplete combustion. It is a high production volume 
chemical in the United States with the majority of its use in the 
synthesis of acetone and phenol. Additional information about the 
review of cumene for the RoC is available at http://ntp.niehs.nih.gov/go/37895.
    Meeting and Registration: The meeting is open to the public with 
time set aside for oral public comment; attendance at the NIEHS is 
limited only by the space available. The meeting is scheduled for March 
21, 2013, 1:00 p.m. to approximately 5:00 p.m. EDT and March 22, 2013, 
from 8:30 a.m. until adjournment, approximately 2:00 p.m. EDT. Two days 
are set aside for the meeting; however, it may adjourn sooner if the 
panel completes its peer review of the draft monographs. Pre-
registration to attend the meeting and/or provide oral comments is by 
March 19, 2013, at http://ntp.niehs.nih.gov/go/36639. Visitor and 
security information is available at http://www.niehs.nih.gov/about/visiting/index.cfm. Individuals with disabilities who need 
accommodation to participate in this event should contact Danica 
Andrews at phone: (919) 541-2595 or email: andrewsda@niehs.nih.gov. TTY 
users should contact the Federal TTY Relay Service at (800) 877-8339. 
Requests should be made at least five business days in advance of the 
    The preliminary agenda and draft monographs should be posted on the 
NTP Web site (http://ntp.niehs.nih.gov/go/36639) by January 23, 2013. 
Additional information will be posted when available or may be 
requested in hardcopy, see FOR FURTHER INFORMATION CONTACT. Following 
the meeting, a report of the peer review will be prepared and made 
available on the NTP Web site. Registered attendees are encouraged to 
access the meeting Web page to stay abreast of the most current 
information regarding the meeting.
    Request for Comments: The NTP invites written and oral public 
comments on the draft monographs. The deadline for submission of 
written comments is March 7, 2013, to enable review by the peer review 
panel and NTP staff prior to the meeting. Pre-registration to provide 
oral comments is by March 19, 2013, at http://ntp.niehs.nih.gov/go/36639. Public comments and any other correspondence on the draft 
monographs should be sent to the FOR FURTHER INFORMATION CONTACT. 
Persons submitting written comments should include their name, 
affiliation, mailing address, phone, email, and sponsoring organization 
(if any) with the document. Written comments received in response to 
this notice will be posted on the NTP Web site, and the submitter will 
be identified by name, affiliation, and/or sponsoring organization.
    Public comment at this meeting is welcome, with time set aside for 
the presentation of oral comments on the draft monographs. In addition 
to in-person oral comments at the meeting at the NIEHS, public comments 
can be presented by teleconference line. There will be 50 lines for 
this call; availability will be on a first-come, first-served basis. 
The lines will be open from 1:00 p.m. until approximately 5:00 p.m. EDT 
on March 21 and from 8:30 a.m. EDT until adjournment on March 22, 
although oral comments will be received only during the formal public 
comment periods indicated on the preliminary agenda. Each organization 
is allowed one time slot. At least 7 minutes will be allotted to each 
speaker, and if time permits, may be extended to 10 minutes at the 
discretion of the chair. Persons wishing to make an oral presentation 
are asked to register online at http://ntp.niehs.nih.gov/go/36639 by 
March 19, 2013, and if possible, to send a copy of their slides and/or 
statement or talking points at that time. Written statements can 
supplement and may expand the oral presentation. Registration for oral 
comments will also be available at the meeting, although time allowed 
for presentation by on-site registrants may be less than that for pre-
registered speakers and will be determined by the number of speakers 
who register on-site.
    Background Information on the RoC: Published biennially, each 
edition of the RoC is cumulative and consists of substances newly 
reviewed in addition to those listed in previous editions. The 12th 
RoC, the latest edition, was published on June 10, 2011 (available at

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http://ntp.niehs.nih.gov/go/roc12). The 13th RoC is under development. 
For each listed substance, the RoC contains a substance profile, which 
provides information on: Cancer studies that support the listing--
including those in humans, animals, and studies on possible mechanisms 
of action--information about potential sources of exposure to humans, 
and current Federal regulations to limit exposures.
    Background Information on NTP Peer Review Panels: NTP panels are 
technical, scientific advisory bodies established on an ``as needed'' 
basis to provide independent scientific peer review and advise the NTP 
on agents of public health concern, new/revised toxicological test 
methods, or other issues. These panels help ensure transparent, 
unbiased, and scientifically rigorous input to the program for its use 
in making credible decisions about human hazard, setting research and 
testing priorities, and providing information to regulatory agencies 
about alternative methods for toxicity screening. The NTP welcomes 
nominations of scientific experts for upcoming panels. Scientists 
interested in serving on an NTP panel should provide a current 
curriculum vitae to the FOR FURTHER INFORMATION CONTACT. The authority 
for NTP panels is provided by 42 U.S.C. 217a; section 222 of the Public 
Health Service (PHS) Act, as amended. The panel is governed by the 
Federal Advisory Committee Act, as amended (5 U.S.C. Appendix 2), which 
sets forth standards for the formation and use of advisory committees.

    Dated: January 16, 2013.
John R. Bucher,
Associate Director, National Toxicology Program.
[FR Doc. 2013-01242 Filed 1-18-13; 8:45 am]